The objectives of the study were first to assess influence of age on nurses’ job satisfaction and secondly, determine influence of education on the same emotion. Research design was cross- sectional involving a sample size of 75 respondents. Purposive and judgmental sampling procedures were used. Interview was used as method for data collection. The tool for data collection was questionnaire. Data analysis employed percentages, mean and One-Way ANOVA test. Statistical Package for Social Science was a tool for data analysis. Results revealed that there was significant difference in job satisfaction by age groups and levels of education (p˃0.05). Overall results revealed that age was not significantly influencing job satisfaction whereby the leading job dissatisfaction was among 29 to 38 years old and the oldestage.It was further revealed that education unlike agehad great influence towards respondents’ job satisfaction as Post Graduates were mostly satisfied with all job aspects. It was recommended that Ministry of Health, Community Development, Gender, Elderly and Childrenformulates and effectively implements policies targeting job satisfaction enhancement in general and pay attention to the needs of each dissatisfied age group and lower levels of education to raise their satisfaction for benefits of patients referredto this hospital from rural and urban Tanzania.